From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
Identifieur interne : 001C08 ( Main/Exploration ); précédent : 001C07; suivant : 001C09From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
Auteurs : Rolf Hilgenfeld [Allemagne] ; Malik Peiris [Hong Kong]Source :
- Antiviral research [ 0166-3542 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Coronaviridae (génétique), Coronaviridae (physiologie), Humains, Infections à Coronaviridae (traitement médicamenteux), Infections à Coronaviridae (virologie), Recherche biomédicale (tendances), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
- génétique : Coronaviridae, Virus du SRAS.
- physiologie : Coronaviridae, Virus du SRAS.
- tendances : Recherche biomédicale.
- traitement médicamenteux : Infections à Coronaviridae, Syndrome respiratoire aigu sévère.
- virologie : Infections à Coronaviridae, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Animals, Antiviral, Biomedical Research (trends), Coronaviridae (genetics), Coronaviridae (physiology), Coronaviridae Infections (drug therapy), Coronaviridae Infections (virology), Coronavirus, Human, Humans, Immunoprophylaxis, Middle East respiratory syndrome, Pathogenic, Prevention, SARS Virus (genetics), SARS Virus (physiology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Structure activity relation, Treatment, Vaccine.
- MESH :
- drug therapy : Coronaviridae Infections, Severe Acute Respiratory Syndrome.
- genetics : Coronaviridae, SARS Virus.
- physiology : Coronaviridae, SARS Virus.
- trends : Biomedical Research.
- virology : Coronaviridae Infections, Severe Acute Respiratory Syndrome.
- Animals, Humans.
Abstract
This article introduces a series of invited papers in Antiviral Research marking the 10th anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a novel coronavirus that emerged in southern China in late 2002. Until that time, coronaviruses had not been recognized as agents causing severe disease in humans, hence, the emergence of the SARS-CoV came as a complete surprise. Research during the past ten years has revealed the existence of a diverse pool of coronaviruses circulating among various bat species and other animals, suggesting that further introductions of highly pathogenic coronaviruses into the human population are not merely probable, but inevitable. The recent emergence of another coronavirus causing severe disease, Middle East respiratory syndrome (MERS), in humans, has made it clear that coronaviruses pose a major threat to human health, and that more research is urgently needed to elucidate their replication mechanisms, identify potential drug targets, and develop effective countermeasures. In this series, experts in many different aspects of coronavirus replication and disease will provide authoritative, up-to-date reviews of the following topics: - clinical management and infection control of SARS; - reservoir hosts of coronaviruses; - receptor recognition and cross-species transmission of SARS-CoV; - SARS-CoV evasion of innate immune responses; - structures and functions of individual coronaviral proteins; - anti-coronavirus drug discovery and development; and - the public health legacy of the SARS outbreak. Each article will be identified in the last line of its abstract as belonging to the series "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses."
Url:
Affiliations:
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Le document en format XML
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xml:lang="fr"><term>Homme</term><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This article introduces a series of invited papers in Antiviral Research marking the 10th anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a novel coronavirus that emerged in southern China in late 2002. Until that time, coronaviruses had not been recognized as agents causing severe disease in humans, hence, the emergence of the SARS-CoV came as a complete surprise. Research during the past ten years has revealed the existence of a diverse pool of coronaviruses circulating among various bat species and other animals, suggesting that further introductions of highly pathogenic coronaviruses into the human population are not merely probable, but inevitable. The recent emergence of another coronavirus causing severe disease, Middle East respiratory syndrome (MERS), in humans, has made it clear that coronaviruses pose a major threat to human health, and that more research is urgently needed to elucidate their replication mechanisms, identify potential drug targets, and develop effective countermeasures. In this series, experts in many different aspects of coronavirus replication and disease will provide authoritative, up-to-date reviews of the following topics: - clinical management and infection control of SARS; - reservoir hosts of coronaviruses; - receptor recognition and cross-species transmission of SARS-CoV; - SARS-CoV evasion of innate immune responses; - structures and functions of individual coronaviral proteins; - anti-coronavirus drug discovery and development; and - the public health legacy of the SARS outbreak. Each article will be identified in the last line of its abstract as belonging to the series "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses."</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Hong Kong</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name></noRegion><name sortKey="Hilgenfeld, Rolf" sort="Hilgenfeld, Rolf" uniqKey="Hilgenfeld R" first="Rolf" last="Hilgenfeld">Rolf Hilgenfeld</name></country><country name="Hong Kong"><noRegion><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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